Selphyller PRFM Plasma Gel: Natural Biologic Filler
Natural Biologic Filler
Selphyller PRFM Plasma Gel™ is a natural, biologic filler created entirely from your own blood. Designed as an alternative to synthetic dermal fillers, Selphyller offers gentle structural support while integrating seamlessly with the body’s natural processes. Rather than replacing volume with synthetic substances, Selphyller supports the skin using material your body already recognizes — resulting in subtle, balanced outcomes that align with natural facial anatomy.
How Selphyller PRFM Plasma Gel Works
Selphyller begins with a small blood draw, which is processed using a specialized system that concentrates platelets and fibrin into a platelet-rich fibrin matrix. This PRFM is then gently heated to convert it into a smooth plasma gel that can be injected into targeted areas of the face.
Once placed, the plasma gel provides natural structural support while introducing platelet-rich components that may help support tissue quality over time. The fibrin matrix allows the gel to integrate gradually, rather than sitting rigidly beneath the skin. Because Selphyller is made from your own biologic material, results tend to develop softly and naturally — supporting facial contour and skin quality without abrupt or overfilled changes.
Why We Love Selphyller
Naturally Derived, Biologic Material
Selphyller is created entirely from your own blood, offering a natural filler option without synthetic ingredients.
Subtle Volume Support
This treatment provides gentle structural reinforcement rather than dramatic filling, making it well-suited for delicate areas or patients who prefer understated results.
Supports Skin Quality Over Time
The platelet-rich fibrin matrix introduces biologic components that may contribute to improved tissue resilience and skin texture.
Gradual, Natural Integration
Selphyller integrates slowly into surrounding tissue, helping results look balanced and harmonious as they develop.
Complements Other Treatments
Selphyller can be incorporated alongside neuromodulators, traditional fillers, and skin-quality treatments for a comprehensive, natural approach to facial aging.
Treatment Expectations and Care
Limit alcohol
Avoid alcohol for 24–48 hours prior to treatment when possible to reduce bruising risk.
Review medications and supplements
If medically appropriate, avoid aspirin, ibuprofen/NSAIDs, and blood-thinning supplements such as fish oil, Vitamin E, or ginkgo. Do not stop prescribed medications without guidance from your prescribing clinician.
Pause active skincare
Discontinue retinoids, exfoliating acids, and strong actives on treatment areas for several days beforehand.
Arrive with clean skin
Come with minimal or no makeup on planned injection sites when possible.
Share your health history
Inform your provider of allergies, medical conditions, bleeding or autoimmune disorders, recent procedures, or upcoming treatments.
Pregnancy and breastfeeding
Selphyller PRFM Plasma Gel™ is not recommended during pregnancy or breastfeeding.
Appointment length
Most Selphyller treatments take approximately 45–60 minutes.
Injection technique
A small amount of blood is drawn to prepare the PRFM plasma gel.
Plasma gel preparation
The PRFM is processed and converted into a gel-like consistency prior to injection.
Injection approach
The plasma gel is carefully placed into targeted areas to support contour and tissue quality.
Precision and balance
Placement is guided by facial anatomy and overall harmony rather than isolated correction.
Avoid pressure
Do not touch, rub, or massage treated areas for at least 24 hours unless otherwise directed.
Activity considerations
Avoid strenuous exercise for 24–48 hours to help minimize swelling or bruising.
Limit heat & alcohol
Avoid alcohol, saunas, hot tubs, and prolonged sun exposure for at least 24 hours.
Normal responses
Mild swelling, redness, tenderness, or bruising may occur and typically resolves within several days.
Results timeline
Initial changes may be subtle, with gradual improvement as the plasma gel integrates.
Follow-up
A follow-up visit may be recommended once results have settled to assess balance and determine whether refinement is appropriate.
Pricing
Selphyller PRFM Plasma Gel pricing is based on the treatment area and the amount of plasma gel prepared. During your consultation, your provider will review options and create a personalized plan aligned with your goals and anatomy.
Frequently Asked Questions
Is Selphyller a natural filler?
Yes. Selphyller is created entirely from your own blood, making it a natural, biologically compatible plasma gel filler.
How is Selphyller different from traditional dermal fillers?
Unlike synthetic fillers, Selphyller uses your body’s own platelet-rich material to provide subtle volume support and skin refinement.
Does Selphyller stimulate collagen?
Selphyller contains platelet-rich components that may support tissue quality, though individual responses vary and results develop gradually.
Is there downtime?
Downtime is minimal. Mild swelling or bruising may occur and typically resolves within a few days.
When will I see results?
Results develop gradually as the plasma gel integrates, with continued refinement over time.
Who is a good candidate?
Patients seeking a natural filler alternative with subtle volume support and biologic compatibility may be good candidates following consultation.